The Cyber Threat Landscape and Threat Prediction report is an annual evaluation of the state of cybersecurity, highlighting the key threats, trends, Threat Actors (TA), and attack methodologies. The Cyber Threat Landscape comprises both potential and identified cyber threats that affect a sector, group of users, or events over a particular period. It is crucial to proactively understand and develop awareness about evolving cyber threats to combat cybercrime. In 2021, Cyble Research Labs examined the cyber threat landscape to analyze various hidden threats, malware, APT campaigns, data leaks, ransomware attacks, phishing campaigns. This report includes the vulnerabilities, malware, Advanced Persistent threats (APTs), and their Tactics, Techniques, Procedures (TTP) active during 2021 along with threat predictions for 2022.